Comprehensive comparison of enzymatic and bisulfite DNA methylation analysis in clinically relevant samples

Abstract Background Bisulfite conversion is considered the gold standard for DNA methylation analysis, but it damages DNA and performs sub-optimally with clinical samples (e.g., formalin-fixed paraffin-embedded and circulating free plasma DNA (cfDNA)). Here we describe a comprehensive comparison of...

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Bibliografische gegevens

Hoofdauteurs:	Barrett Nuttall, Daniel L. Karl, Kathleen Burke, Megan Callahan, Kerrin Mendler, Pablo Cingolani, Steven Criscione, Serhiy Naumenko, Elena Bibikova, Veerendra Munugalavadla, John C. Byrd, Richard R. Furman, Jennifer R. Brown, Andrew Mortlock, Brian A. Dougherty, J. Carl Barrett, Maurizio Scaltriti, James Hadfield
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2025-10-01
Reeks:	Clinical Epigenetics
Onderwerpen:	Methylation Enzymatic methylation sequencing Bisulfite sequencing Targeted methylation sequencing Chronic lymphocytic leukemia
Online toegang:	https://doi.org/10.1186/s13148-025-01959-0
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