Comprehensive comparison of enzymatic and bisulfite DNA methylation analysis in clinically relevant samples

Abstract Background Bisulfite conversion is considered the gold standard for DNA methylation analysis, but it damages DNA and performs sub-optimally with clinical samples (e.g., formalin-fixed paraffin-embedded and circulating free plasma DNA (cfDNA)). Here we describe a comprehensive comparison of...

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Détails bibliographiques

Auteurs principaux:	Barrett Nuttall, Daniel L. Karl, Kathleen Burke, Megan Callahan, Kerrin Mendler, Pablo Cingolani, Steven Criscione, Serhiy Naumenko, Elena Bibikova, Veerendra Munugalavadla, John C. Byrd, Richard R. Furman, Jennifer R. Brown, Andrew Mortlock, Brian A. Dougherty, J. Carl Barrett, Maurizio Scaltriti, James Hadfield
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-10-01
Collection:	Clinical Epigenetics
Sujets:	Methylation Enzymatic methylation sequencing Bisulfite sequencing Targeted methylation sequencing Chronic lymphocytic leukemia
Accès en ligne:	https://doi.org/10.1186/s13148-025-01959-0
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