Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability

Abstract Foot-and-mouth disease virus (FMDV) is a picornavirus that exhibits an extremely acid sensitive capsid. This acid lability is directly related to its mechanism of uncoating triggered by acidification inside cellular endosomes. Using a collection of FMDV mutants we have systematically analyz...

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Hlavní autoři:	Flavia Caridi, Rodrigo Cañas-Arranz, Ángela Vázquez-Calvo, Patricia de León, Katherine I. Calderón, Esteban Domingo, Francisco Sobrino, Miguel A. Martín-Acebes
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2021-12-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-021-02757-3
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