Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability
Abstract Foot-and-mouth disease virus (FMDV) is a picornavirus that exhibits an extremely acid sensitive capsid. This acid lability is directly related to its mechanism of uncoating triggered by acidification inside cellular endosomes. Using a collection of FMDV mutants we have systematically analyz...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2021-12-01
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| Serie: | Scientific Reports |
| Accesso online: | https://doi.org/10.1038/s41598-021-02757-3 |
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