Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus.

Eitemau Tebyg

• Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades.
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• Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection.
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• Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell culture.
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• Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.
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  Cyhoeddwyd: (1991)
• Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg-Gly-Asp motif in the interaction.
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