Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus.

We provide evidence that the quasispecies nature (extreme genetic heterogeneity) of foot-and-mouth disease virus is relevant to the virus evading an immune response. A monoclonal antibody neutralizing the viral infectivity (clone SD6) recognizes an epitope located around a highly conserved sequence...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Mateu, M G, Martínez, M A, Rocha, E, Andreu, D, Parejo, J, Giralt, E, Sobrino, F, Domingo, E
Format: Artigo
Langue:Inglês
Publié: 1989
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC297735/
https://ncbi.nlm.nih.gov/pubmed/2474821
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