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Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus.

We provide evidence that the quasispecies nature (extreme genetic heterogeneity) of foot-and-mouth disease virus is relevant to the virus evading an immune response. A monoclonal antibody neutralizing the viral infectivity (clone SD6) recognizes an epitope located around a highly conserved sequence...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mateu, M G, Martínez, M A, Rocha, E, Andreu, D, Parejo, J, Giralt, E, Sobrino, F, Domingo, E
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297735/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2474821/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.15.5883
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