Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Anaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK. However, continuous treatment with ALKis invariably leads to acquired resistance in cancer cells. In this study, we pro...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2025-04-01
Sarja:	Molecular Oncology
Aiheet:	acquired resistance ALK inhibitors connectivity map emetine transcriptome‐based drug repositioning
Linkit:	https://doi.org/10.1002/1878-0261.13738
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