Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Anaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK. However, continuous treatment with ALKis invariably leads to acquired resistance in cancer cells. In this study, we pro...

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Detalhes bibliográficos

Principais autores:	Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-04-01
coleção:	Molecular Oncology
Assuntos:	acquired resistance ALK inhibitors connectivity map emetine transcriptome‐based drug repositioning
Acesso em linha:	https://doi.org/10.1002/1878-0261.13738
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