Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Anaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK. However, continuous treatment with ALKis invariably leads to acquired resistance in cancer cells. In this study, we pro...

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Egile Nagusiak:	Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Wiley 2025-04-01
Saila:	Molecular Oncology
Gaiak:	acquired resistance ALK inhibitors connectivity map emetine transcriptome‐based drug repositioning
Sarrera elektronikoa:	https://doi.org/10.1002/1878-0261.13738
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