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Reduced PI3K(p110α) induces atrial myopathy, and PI3K-related lipids are dysregulated in athletes with atrial fibrillation

Background: Elucidating mechanisms underlying atrial myopathy, which predisposes individuals to atrial fibrillation (AF), will be critical for preventing/treating AF. In a serendipitous discovery, we identified atrial enlargement, fibrosis, and thrombi in mice with reduced phosphoinositide 3-kinase...

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Asıl Yazarlar: Sebastian Bass-Stringer, Bianca C. Bernardo, Gunes S. Yildiz, Aya Matsumoto, Helen Kiriazis, Claudia A. Harmawan, Celeste M.K. Tai, Roger Chooi, Lauren Bottrell, Martin Ezeani, Daniel G. Donner, Aascha A. D'Elia, Jenny Y.Y. Ooi, Natalie A. Mellett, Jieting Luo, Emma I. Masterman, Kristel Janssens, Gavriel Olshansky, Erin J. Howden, Jonathon H. Cross, Christoph E. Hagemeyer, Ruby C.Y. Lin, Colleen J. Thomas, Graham W. Magor, Andrew C. Perkins, Thomas H. Marwick, Hiroshi Kawakami, Peter J. Meikle, David W. Greening, Kate L. Weeks, André La Gerche, Yow Keat Tham, Julie R. McMullen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2025-12-01
Seri Bilgileri:Journal of Sport and Health Science
Konular:
Atrial myopathy
Atrial fibrillation
Lipidomics
Proteomics
Exercise
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2095254625000018
Etiketler: Etiketle
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