Reduced PI3K(p110α) induces atrial myopathy, and PI3K-related lipids are dysregulated in athletes with atrial fibrillation

Background: Elucidating mechanisms underlying atrial myopathy, which predisposes individuals to atrial fibrillation (AF), will be critical for preventing/treating AF. In a serendipitous discovery, we identified atrial enlargement, fibrosis, and thrombi in mice with reduced phosphoinositide 3-kinase...

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Principais autores:	Sebastian Bass-Stringer, Bianca C. Bernardo, Gunes S. Yildiz, Aya Matsumoto, Helen Kiriazis, Claudia A. Harmawan, Celeste M.K. Tai, Roger Chooi, Lauren Bottrell, Martin Ezeani, Daniel G. Donner, Aascha A. D'Elia, Jenny Y.Y. Ooi, Natalie A. Mellett, Jieting Luo, Emma I. Masterman, Kristel Janssens, Gavriel Olshansky, Erin J. Howden, Jonathon H. Cross, Christoph E. Hagemeyer, Ruby C.Y. Lin, Colleen J. Thomas, Graham W. Magor, Andrew C. Perkins, Thomas H. Marwick, Hiroshi Kawakami, Peter J. Meikle, David W. Greening, Kate L. Weeks, André La Gerche, Yow Keat Tham, Julie R. McMullen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-12-01
Series:	Journal of Sport and Health Science
Assuntos:	Atrial myopathy Atrial fibrillation Lipidomics Proteomics Exercise
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2095254625000018
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