Reduced PI3K(p110α) induces atrial myopathy, and PI3K-related lipids are dysregulated in athletes with atrial fibrillation

Background: Elucidating mechanisms underlying atrial myopathy, which predisposes individuals to atrial fibrillation (AF), will be critical for preventing/treating AF. In a serendipitous discovery, we identified atrial enlargement, fibrosis, and thrombi in mice with reduced phosphoinositide 3-kinase...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sebastian Bass-Stringer, Bianca C. Bernardo, Gunes S. Yildiz, Aya Matsumoto, Helen Kiriazis, Claudia A. Harmawan, Celeste M.K. Tai, Roger Chooi, Lauren Bottrell, Martin Ezeani, Daniel G. Donner, Aascha A. D'Elia, Jenny Y.Y. Ooi, Natalie A. Mellett, Jieting Luo, Emma I. Masterman, Kristel Janssens, Gavriel Olshansky, Erin J. Howden, Jonathon H. Cross, Christoph E. Hagemeyer, Ruby C.Y. Lin, Colleen J. Thomas, Graham W. Magor, Andrew C. Perkins, Thomas H. Marwick, Hiroshi Kawakami, Peter J. Meikle, David W. Greening, Kate L. Weeks, André La Gerche, Yow Keat Tham, Julie R. McMullen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-12-01
Schriftenreihe:	Journal of Sport and Health Science
Schlagworte:	Atrial myopathy Atrial fibrillation Lipidomics Proteomics Exercise
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2095254625000018
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!