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A Novel Method for Separating Full and Empty Adeno-Associated Viral Capsids Using Ultrafiltration

Adeno-associated viral vectors (AAVs) are the predominant viral vectors used for gene therapy applications. A significant challenge in obtaining effective doses is removing non-therapeutic empty viral capsids lacking DNA cargo. Current methods for separating full (gene-containing) and empty capsids...

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Principais autores: Deepraj Sarmah, Scott M. Husson
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-09-01
Serier:Membranes
Fag:
AAV purification
AAV ultrafiltration
AAV membrane filtration
AAV PCTE membrane
AAV infectivity
AAV live cell imaging
Online adgang:https://www.mdpi.com/2077-0375/14/9/194
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