Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes

Alterations in subcortical brain structure volumes have been found to be associated with several neurodegenerative and psychiatric disorders. At the same time, genome-wide association studies (GWAS) have identified numerous common variants associated with brain structure. In this study, we integrate...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Pritesh R Jain, Madison Yates, Carlos Rubin de Celis, Petros Drineas, Neda Jahanshad, Paul Thompson, Peristera Paschou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-12-01
Schriftenreihe:	NeuroImage
Schlagworte:	Subcortical brain volume Proteome Metabolites Mendelian randomization Neurological disorders
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1053811923006171
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!