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Activation of Platelet NLRP3 Inflammasome in Crohn’s Disease

Patients with Crohn’s disease (CD) are inclined to have platelet hyperactivity and an increased risk of intestinal micro-thrombosis. However, the mechanisms underlying platelet hyperactivity in CD are not well understood. We investigated the assembly of platelet NLRP3 inflammasome in patients with a...

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Principais autores: Ge Zhang, He Chen, Yifan Guo, Wei Zhang, Qiuyu Jiang, Si Zhang, Liping Han, She Chen, Ruyi Xue
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-06-01
Serier:Frontiers in Pharmacology
Fag:
NLRP3 inflammasome
Crohn’s disease
platelet hyperactivity
ROS
interleukin-1β
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.705325/full
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