LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease states and is considered an attractive therapeutic t...

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Hlavní autoři:	Jack P Green, Tessa Swanton, Lucy V Morris, Lina Y El-Sharkawy, James Cook, Shi Yu, James Beswick, Antony D Adamson, Neil E Humphreys, Richard Bryce, Sally Freeman, Catherine Lawrence, David Brough
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2020-11-01
Edice:	eLife
Témata:	Inflammation NLRP3 inflammasome interleukin-1β chloride VRAC RVD
On-line přístup:	https://elifesciences.org/articles/59704
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