LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease states and is considered an attractive therapeutic t...

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Autors principals:	Jack P Green, Tessa Swanton, Lucy V Morris, Lina Y El-Sharkawy, James Cook, Shi Yu, James Beswick, Antony D Adamson, Neil E Humphreys, Richard Bryce, Sally Freeman, Catherine Lawrence, David Brough
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2020-11-01
Col·lecció:	eLife
Matèries:	Inflammation NLRP3 inflammasome interleukin-1β chloride VRAC RVD
Accés en línia:	https://elifesciences.org/articles/59704
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