Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

Summary: Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development, including NK cells. To determine if Hhex is intrinsically required...

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Библиографические подробности

Главные авторы:	Wilford Goh, Sebastian Scheer, Jacob T. Jackson, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Iona S. Schuster, Christopher E. Andoniou, Jai Rautela, Mariapia A. Degli-Esposti, Melissa J. Davis, Matthew P. McCormack, Stephen L. Nutt, Nicholas D. Huntington
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2020-10-01
Серии:	Cell Reports
Предметы:	NK cells proliferation survival apoptosis BIM transcriptional regulation
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2211124720312742
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