Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

Summary: Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development, including NK cells. To determine if Hhex is intrinsically required...

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Autori principali:	Wilford Goh, Sebastian Scheer, Jacob T. Jackson, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Iona S. Schuster, Christopher E. Andoniou, Jai Rautela, Mariapia A. Degli-Esposti, Melissa J. Davis, Matthew P. McCormack, Stephen L. Nutt, Nicholas D. Huntington
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2020-10-01
Serie:	Cell Reports
Soggetti:	NK cells proliferation survival apoptosis BIM transcriptional regulation
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124720312742
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