Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

Summary: Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development, including NK cells. To determine if Hhex is intrinsically required...

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Detalhes bibliográficos

Principais autores:	Wilford Goh, Sebastian Scheer, Jacob T. Jackson, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Iona S. Schuster, Christopher E. Andoniou, Jai Rautela, Mariapia A. Degli-Esposti, Melissa J. Davis, Matthew P. McCormack, Stephen L. Nutt, Nicholas D. Huntington
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-10-01
coleção:	Cell Reports
Assuntos:	NK cells proliferation survival apoptosis BIM transcriptional regulation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124720312742
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