Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain

Acute brain injury leads to the recruitment and activation of immune cells including resident microglia and infiltrating peripheral myeloid cells (MC), which contribute to the inflammatory response involved in neuronal damage. We previously reported that TLR2 stimulation by peptidoglycan (PGN) from...

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Hauptverfasser:	Daniela S. Arroyo, Emilia A. Gaviglio, Javier M. Peralta Ramos, Claudio Bussi, Maria P. Avalos, Liliana M. Cancela, Pablo Iribarren
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2018-04-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	myeloid cells phosphatidyl-inositol-3 kinase inhibitors autophagy peptidoglycan TLR2 inflammation
Online-Zugang:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00770/full
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