Immunotherapy to improve cognition and reduce pathological species in an Alzheimer’s disease mouse model

Abstract Background Alzheimer’s disease (AD) is characterized by physiologically endogenous proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating as soluble oligomers and insoluble aggregates. Tau and Aβ soluble oligomers, which contain extensive β-sheet secondary st...

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Bibliografische Detailangaben

Hauptverfasser:	Krystal Herline, Frances Prelli, Pankaj Mehta, Claire MacMurray, Fernando Goñi, Thomas Wisniewski
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2018-06-01
Schriftenreihe:	Alzheimer’s Research & Therapy
Schlagworte:	Alzheimer’s disease Amyloid-beta (Aβ) Phosphorylated tau Oligomers Passive immunization Monoclonal antibody
Online-Zugang:	http://link.springer.com/article/10.1186/s13195-018-0384-9
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