Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development.

OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect of OBF1 deficient mice is a severely reduced...

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Główni autorzy:	Alain Bordon, Nabil Bosco, Camille Du Roure, Boris Bartholdy, Hubertus Kohler, Gabriele Matthias, Antonius G Rolink, Patrick Matthias
Format:	Artigo
Język:	Inglês
Wydane:	Public Library of Science (PLoS) 2008-01-01
Seria:	PLoS ONE
Dostęp online:	http://europepmc.org/articles/PMC2603323?pdf=render
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