Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development.
OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect of OBF1 deficient mice is a severely reduced...
Tallennettuna:
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science (PLoS)
2008-01-01
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| Sarja: | PLoS ONE |
| Linkit: | http://europepmc.org/articles/PMC2603323?pdf=render |
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