Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development.

OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect of OBF1 deficient mice is a severely reduced...

Полное описание

Библиографические подробности

Главные авторы:	Alain Bordon, Nabil Bosco, Camille Du Roure, Boris Bartholdy, Hubertus Kohler, Gabriele Matthias, Antonius G Rolink, Patrick Matthias
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2008-01-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC2603323?pdf=render
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