TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5

<p>Abstract</p> <p>Background</p> <p>Overactivated microglia that cluster at neuritic plaques constantly release neurotoxins, which actively contribute to progressive neurodegeneration in Alzheimer's disease (AD). Therefore, attenuating microglial clustering can reduce focal neuroinflammation at neu...

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Detalhes bibliográficos

Principais autores:	Huang Fong-Lee, Yang Cheng-Ning, Shiao Young-Ji, Pan Chih-Ming, Shie Feng-Shiun, Yen Feng-Chang, Huang Wei-Chao, Sung Yen-Jen, Tsay Huey-Jen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2010-04-01
Colecção:	Journal of Neuroinflammation
Acesso em linha:	http://www.jneuroinflammation.com/content/7/1/28
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