Amyloid β peptide promotes lysosomal degradation of clusterin via sortilin in hippocampal primary neurons

Progressive accumulation of amyloid-β peptide (Aβ) in the brain is implicated as the central event in the development of Alzheimer's disease (AD). It is thought that extracellular Aβ triggers toxic signals leading to neurodegeneration. The events downstream of Aβ however are not entirely clear. Clus...

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Detalles Bibliográficos

Autores principales:	Yunling Wang, Xike Qin, Hemant K. Paudel
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2017-07-01
Colección:	Neurobiology of Disease
Materias:	Amyloid-β Clusterin Sortilin Lysosomal degradation Alzheimer's disease
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0969996117300797
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