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Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer’s Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance

Dihydroartemisinin (DHA) is an active metabolite of sesquiterpene trioxane lactone extracted from Artemisia annua, which is used to treat malaria worldwide. DHA can activate autophagy, which is the main mechanism to remove the damaged cell components and recover the harmful or useless substances fro...

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Principais autores: Yueyang Zhao, Zhimin Long, Ya Ding, Tingting Jiang, Jiajun Liu, Yimin Li, Yuanjie Liu, Xuehua Peng, Kejian Wang, Min Feng, Guiqiong He
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-03-01
coleção:Frontiers in Aging Neuroscience
Assuntos:
Alzheimer’s disease
amyloid-beta
dihydroartemisinin
autophagic flux
autolysosomal degradation
autophagosome-lysosome fusion
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnagi.2020.00047/full
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