Microglia TFEB activation attenuates Alzheimer’s disease pathology by enhancing autophagy-lysosomal function

Abstract Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) accumulation, neuroinflammation, synaptic dysfunction, and cognitive decline. Impairment of microglial autophagy-lysosomal pathway (ALP) is increasingly recognized as a key driver of the disease progression. Transcription factor EB...

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Detalhes bibliográficos

Principais autores:	Yeji Kim, Tae-Young Ha, Oksana Kondaurova, Myung-Shik Lee, Keun-A Chang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Journal of Neuroinflammation
Assuntos:	TFEB Microglia Alzheimer’s disease Autophagy-lysosomal pathway Amyloid beta Neuroinflammation
Acesso em linha:	https://doi.org/10.1186/s12974-026-03728-z
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