Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome pathway (ALP) are the two major protein degradation pathways, which are critical for proteostasis. Growing evidence indicates that proteasome inhibition-induced ALP activation is an adaptive response. Transcription Factor EB (TFEB) is a maste...

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書誌詳細

主要な著者:	Chunyan Li, Xin Wang, Xuezhi Li, Kaixin Qiu, Fengjuan Jiao, Yidan Liu, Qingxia Kong, Yan Liu, Yili Wu
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2019-08-01
シリーズ:	Frontiers in Cell and Developmental Biology
主題:	ubiquitin-proteasome pathway autophagy-lysosome pathway TFEB TFEB nuclear translocation TFEB dephosphorylation
オンライン･アクセス:	https://www.frontiersin.org/article/10.3389/fcell.2019.00170/full
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