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Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

Abstract Background Among the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria determining lysosomal degradation of mitochondrial damaged proteins. In this context, RAB7, a late endocytic smal...

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Principais autores: Sinforosa Gagliardi, Marco Mitruccio, Riccardo Di Corato, Roberta Romano, Alessandra Aloisi, Rosaria Rinaldi, Pietro Alifano, Flora Guerra, Cecilia Bucci
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-03-01
Series:Cell Communication and Signaling
Assuntos:
RAB7
Mitochondria-derived vesicles
Extracellular vesicles
Cisplatin chemoresistance
Ovarian cancer
Acceso en liña:https://doi.org/10.1186/s12964-024-01507-y
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