Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

Abstract Background Among the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria determining lysosomal degradation of mitochondrial damaged proteins. In this context, RAB7, a late endocytic smal...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Sinforosa Gagliardi, Marco Mitruccio, Riccardo Di Corato, Roberta Romano, Alessandra Aloisi, Rosaria Rinaldi, Pietro Alifano, Flora Guerra, Cecilia Bucci
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-03-01
coleção:	Cell Communication and Signaling
Assuntos:	RAB7 Mitochondria-derived vesicles Extracellular vesicles Cisplatin chemoresistance Ovarian cancer
Acesso em linha:	https://doi.org/10.1186/s12964-024-01507-y
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!