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Dynamics and quantitative contribution of the aminoglycoside 6′-N-acetyltransferase type Ib to amikacin resistance

ABSTRACTAminoglycosides are essential components in the available armamentarium to treat bacterial infections. The surge and rapid dissemination of resistance genes strongly reduce their efficiency, compromising public health. Among the multitude of modifying enzymes that confer resistance to aminog...

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Principais autores: Ophélie d’Udekem d’Acoz, Fong Hue, Tianyi Ye, Louise Wang, Maxime Leroux, Lucila Rajngewerc, Tung Tran, Kimberly Phan, Maria S. Ramirez, Walter Reisner, Marcelo E. Tolmasky, Rodrigo Reyes-Lamothe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2024-03-01
Serier:mSphere
Fag:
amikacin
antibiotic resistance
fluorescence
AAC(6′)-Ib
Escherichia coli
CRISPRi
Online adgang:https://journals.asm.org/doi/10.1128/msphere.00789-23
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