Systematic Analysis of a Conserved Region of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

Alanine-scanning mutagenesis was applied to the aminoglycoside 6′-N-acetyltransferase type Ib conserved motif B, and the effects of the substitutions were analyzed by measuring the MICs of kanamycin (KAN) and its semisynthetic derivative, amikacin (AMK). Several substitutions resulted in no major ch...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shmara, Ali, Weinsetel, Natalia, Dery, Ken J., Chavideh, Ramona, Tolmasky, Marcelo E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2001
Pynciau:
Mechanisms of Resistance
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC90828/
https://ncbi.nlm.nih.gov/pubmed/11709299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3287-3292.2001
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