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Systematic Analysis of a Conserved Region of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

Alanine-scanning mutagenesis was applied to the aminoglycoside 6′-N-acetyltransferase type Ib conserved motif B, and the effects of the substitutions were analyzed by measuring the MICs of kanamycin (KAN) and its semisynthetic derivative, amikacin (AMK). Several substitutions resulted in no major ch...

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Detaylı Bibliyografya
Asıl Yazarlar: Shmara, Ali, Weinsetel, Natalia, Dery, Ken J., Chavideh, Ramona, Tolmasky, Marcelo E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2001
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC90828/
https://ncbi.nlm.nih.gov/pubmed/11709299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3287-3292.2001
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