Systematic Analysis of a Conserved Region of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

Alanine-scanning mutagenesis was applied to the aminoglycoside 6′-N-acetyltransferase type Ib conserved motif B, and the effects of the substitutions were analyzed by measuring the MICs of kanamycin (KAN) and its semisynthetic derivative, amikacin (AMK). Several substitutions resulted in no major ch...

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Main Authors: Shmara, Ali, Weinsetel, Natalia, Dery, Ken J., Chavideh, Ramona, Tolmasky, Marcelo E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC90828/
https://ncbi.nlm.nih.gov/pubmed/11709299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3287-3292.2001
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