Systematic Analysis of a Conserved Region of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

Alanine-scanning mutagenesis was applied to the aminoglycoside 6′-N-acetyltransferase type Ib conserved motif B, and the effects of the substitutions were analyzed by measuring the MICs of kanamycin (KAN) and its semisynthetic derivative, amikacin (AMK). Several substitutions resulted in no major ch...

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Détails bibliographiques
Auteurs principaux: Shmara, Ali, Weinsetel, Natalia, Dery, Ken J., Chavideh, Ramona, Tolmasky, Marcelo E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2001
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC90828/
https://ncbi.nlm.nih.gov/pubmed/11709299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3287-3292.2001
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