Systematic Analysis of a Conserved Region of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

Alanine-scanning mutagenesis was applied to the aminoglycoside 6′-N-acetyltransferase type Ib conserved motif B, and the effects of the substitutions were analyzed by measuring the MICs of kanamycin (KAN) and its semisynthetic derivative, amikacin (AMK). Several substitutions resulted in no major ch...

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izdano v:	Antimicrob Agents Chemother
Principais autores:	Shmara, Ali, Weinsetel, Natalia, Dery, Ken J., Chavideh, Ramona, Tolmasky, Marcelo E.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2001
Teme:	Mechanisms of Resistance
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90828/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3287-3292.2001
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