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p53 and Zinc: A Malleable Relationship

A large percentage of transcription factors require zinc to bind DNA. In this review, we discuss what makes p53 unique among zinc-dependent transcription factors. The conformation of p53 is unusually malleable: p53 binds zinc extremely tightly when folded, but is intrinsically unstable in the absenc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jeung-Hoi Ha, Orjola Prela, Darren R. Carpizo, Stewart N. Loh
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2022-04-01
Cyfres:Frontiers in Molecular Biosciences
Pynciau:
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fmolb.2022.895887/full
Tagiau: Ychwanegu Tag
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