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Monomeric, Oligomeric and Polymeric Proteins in Huntington Disease and Other Diseases of Polyglutamine Expansion

Huntington disease and other diseases of polyglutamine expansion are each caused by a different protein bearing an excessively long polyglutamine sequence and are associated with neuronal death. Although these diseases affect largely different brain regions, they all share a number of characteristic...

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Principais autores: Guylaine Hoffner, Philippe Djian
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2014-03-01
Serier:Brain Sciences
Fag:
huntington disease
huntingtin
protein aggregation
neuronal inclusions
oligomers
fibrils
protein secondary structure
amyloid
β-sheets
neurodegenerative diseases
Online adgang:http://www.mdpi.com/2076-3425/4/1/91
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