Alternative Lengthening of Telomeres: A Prognostic Paradox in Cancer

Telomere maintenance enables unlimited cell proliferation by counteracting telomere erosion. While the majority of tumors activate telomerase, a significant subset—approximately 10–15%—utilizes alternative lengthening of telomeres (ALT), a recombination-based mechanism. ALT-positive cancers are clas...

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Autor principal:	Ji-Yong Sung
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-10-01
Col·lecció:	Cells
Matèries:	alternative lengthening of telomeres (ALT) telomere maintenance mechanisms ATRX/DAXX mutations genomic instability DNA damage response (DDR) glioblastoma (GBM)
Accés en línia:	https://www.mdpi.com/2073-4409/14/20/1613
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