Alternative Lengthening of Telomeres: A Prognostic Paradox in Cancer

Telomere maintenance enables unlimited cell proliferation by counteracting telomere erosion. While the majority of tumors activate telomerase, a significant subset—approximately 10–15%—utilizes alternative lengthening of telomeres (ALT), a recombination-based mechanism. ALT-positive cancers are clas...

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Bibliographic Details
Main Author: Ji-Yong Sung
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-10-01
Series:Cells
Subjects:
alternative lengthening of telomeres (ALT)
telomere maintenance mechanisms
ATRX/DAXX mutations
genomic instability
DNA damage response (DDR)
glioblastoma (GBM)
Online Access:https://www.mdpi.com/2073-4409/14/20/1613
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