Alternative Lengthening of Telomeres: A Prognostic Paradox in Cancer

Telomere maintenance enables unlimited cell proliferation by counteracting telomere erosion. While the majority of tumors activate telomerase, a significant subset—approximately 10–15%—utilizes alternative lengthening of telomeres (ALT), a recombination-based mechanism. ALT-positive cancers are clas...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Hovedforfatter: Ji-Yong Sung
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-10-01
Serier:Cells
Fag:
alternative lengthening of telomeres (ALT)
telomere maintenance mechanisms
ATRX/DAXX mutations
genomic instability
DNA damage response (DDR)
glioblastoma (GBM)
Online adgang:https://www.mdpi.com/2073-4409/14/20/1613
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker