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Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis

Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to contribute to its pathogenesis. In the present stud...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jana Meiners, Vittoria Palmieri, Robert Klopfleisch, Jana-Fabienne Ebel, Lukasz Japtok, Fabian Schumacher, Ayan Mohamud Yusuf, Katrin A. Becker, Julia Zöller, Matthias Hose, Burkhard Kleuser, Dirk M. Hermann, Richard N. Kolesnick, Jan Buer, Wiebke Hansen, Astrid M. Westendorf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-06-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
Citrobacter rodentium
colitis
acid sphingomyelinase
amitriptyline
Th1
Th17
Online-Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2019.01386/full
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