The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling

By promoting ceramide release at the cytosolic membrane leaflet, the neutral sphingomyelinase 2 (NSM) is capable of organizing receptor and signalosome segregation. Its role in T cell receptor (TCR) signaling remained so far unknown. We now show that TCR-driven NSM activation is dispensable for TCR...

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主要な著者:	Charlene Börtlein, Annette Draeger, Roman Schoenauer, Alexander Kuhlemann, Markus Sauer, Sibylle Schneider-Schaulies, Elita Avota
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2018-04-01
シリーズ:	Frontiers in Immunology
主題:	neutral sphingomyelinase 2 T cells ceramides PKCζ the microtubule-organizing center
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00815/full
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