The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling
By promoting ceramide release at the cytosolic membrane leaflet, the neutral sphingomyelinase 2 (NSM) is capable of organizing receptor and signalosome segregation. Its role in T cell receptor (TCR) signaling remained so far unknown. We now show that TCR-driven NSM activation is dispensable for TCR...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Frontiers Media S.A.
2018-04-01
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| Reeks: | Frontiers in Immunology |
| Onderwerpen: | |
| Online toegang: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00815/full |
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