Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation

Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Upon specific ablation of NSM2, T cells proved to be hyper-responsive to CD3/CD28 co-stimulation, in...

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Autores principales:	Maria Nathalia De Lira, Sudha Janaki Raman, Almut Schulze, Sibylle Schneider-Schaulies, Elita Avota
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2020-09-01
Colección:	Frontiers in Molecular Biosciences
Materias:	neutral sphingomyelinase-2 T cell receptor Seahorse XF oxidative phosphorylation ATP-adenosine triphosphate Mitochondria
Acceso en línea:	https://www.frontiersin.org/article/10.3389/fmolb.2020.00217/full
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