Zinc binding groups for histone deacetylase inhibitors
Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency of HDACIs. Due to the high affinity to the zinc ion, hydroxamic acid is the most commonly used ZBG in the structure of...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis Group
2018-01-01
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| Serier: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Fag: | |
| Online adgang: | http://dx.doi.org/10.1080/14756366.2017.1417274 |
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