Astrocyte Infection Is Required for Retrovirus-Induced Spongiform Neurodegeneration Despite Suppressed Viral Protein Expression

The ability of retroviruses (RVs) to cause neurodegeneration is critically dependent upon two activities of the envelope protein (Env). First, Env facilitates viral genome delivery to CNS target cells through receptor binding and membrane fusion. Second, Env expression within one or more targets ind...

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Hlavní autoři:	Sandra M. Cardona, Jaclyn M. Dunphy, Alvin S. Das, Connor R. Lynch, William P. Lynch
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2019-10-01
Edice:	Frontiers in Neuroscience
Témata:	retrovirus neurotropism glia astrocytes neural stem cells neural progenitor cells
On-line přístup:	https://www.frontiersin.org/article/10.3389/fnins.2019.01166/full
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