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Repurposing MK-8245 as a Quorum Sensing Inhibitor to Suppress Virulence and Potentiate Antibiotic Activity in <i>Pseudomonas aeruginosa</i>

<b>Background/Objectives</b>: The rise in multidrug-resistant pathogens such as <i>Pseudomonas aeruginosa</i> (PA), coupled with declining antibiotic development, underscores the need for innovative therapeutic strategies. Repurposing approved drugs provides advantages of safety and rapid developmen...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Giulia Bernabè, Giovanni Marzaro, Mahmoud Elsayed Mosaad Shalata, Daniela Iosob, Valentina Inglima, Massimo Bellato, Ignazio Castagliuolo, Paola Brun
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2025-11-01
Schriftenreihe:Antibiotics
Schlagworte:
biofilm
antimicrobial resistance
virulence
quorum sensing inhibitors
molecular docking
Online-Zugang:https://www.mdpi.com/2079-6382/14/11/1116
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