Revisiting the antizyme 1 – ODC interaction reveals low-nanomolar affinity

Abstract Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is one of the shortest-lived mammalian proteins. Its activity and proteasomal degradation are controlled by antizyme (AZ), which disrupts the active ODC homodimer and exposes proteasome-interacting...

Descripció completa

Dades bibliogràfiques

Autors principals:	Grzegorz P. Bereta, Elżbieta Wątor-Wilk, Paweł Kochanowski, Jakub Nowak, Tomasz Kantyka, Przemysław Grudnik
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2026-04-01
Col·lecció:	Amino Acids
Matèries:	Polyamines Ornithine decarboxylase Antizyme Protein–protein interaction Microscale thermophoresis Surface plasmon resonance
Accés en línia:	https://doi.org/10.1007/s00726-026-03519-z
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!