Revisiting the antizyme 1 – ODC interaction reveals low-nanomolar affinity

Abstract Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is one of the shortest-lived mammalian proteins. Its activity and proteasomal degradation are controlled by antizyme (AZ), which disrupts the active ODC homodimer and exposes proteasome-interacting...

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Bibliografiska uppgifter

Huvudupphov:	Grzegorz P. Bereta, Elżbieta Wątor-Wilk, Paweł Kochanowski, Jakub Nowak, Tomasz Kantyka, Przemysław Grudnik
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Springer 2026-04-01
Serie:	Amino Acids
Ämnen:	Polyamines Ornithine decarboxylase Antizyme Protein–protein interaction Microscale thermophoresis Surface plasmon resonance
Länkar:	https://doi.org/10.1007/s00726-026-03519-z
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