Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations.
The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the alpha site (109K [see text]H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that alpha-cleavage is important for PrP(C) physiology. To gain insights in...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2010-02-01
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| coleção: | PLoS ONE |
| Acesso em linha: | http://europepmc.org/articles/PMC2817006?pdf=render |
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